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Schematic representation of wt and chimeric NaPi cotransporters. The cytoplasmic tails and the extracellular and intracellular loops are indicated in open (for mIIa) and filled (for mIIb) bars. The transmembrane domains are shown in open (for mIIa) and filled (for mIIb) boxes. Chimeric transporters were generated by interchanging either an N-terminal domain (mIIaN-mIIb and mIIbN-mIIa) or the C-terminal tail (mIIa-mIIbCT and mIIb-mIIaCT) of mIIa and mIIb cotransporters.
