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. Author manuscript; available in PMC: 2007 Jun 5.
Published in final edited form as: Neuroscience. 2006 Oct 19;143(1):7–13. doi: 10.1016/j.neuroscience.2006.09.021

Figure 1.

Figure 1

Time-dependent supersensitivity of the (−)DOI-induced neuroendocrine responses in cocaine-treated rats at various post-treatment withdrawal times. The data represent the plasma levels of corticosterone (A) and prolactin (B) in rats treated chronically with saline (1ml/kg, i.p., bid) or cocaine (15mg/kg, i.p., bid) and challenged with saline (1 ml/kg) or (−)DOI (0.5 mg/kg) (mean ± SEM of 8–12 rats per group). **p <0.01, significant effect of (−)DOI compared with the respective saline challenge group. ##p < 0.01, significant effect of (−)DOI challenge in cocaine-treated rats compared with (−)DOI challenge in saline-treated rats (three-way ANOVA and Newman-Keuls multiple range test).