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. 2007 May 29;104(23):9870–9875. doi: 10.1073/pnas.0700436104

Fig. 1.

Fig. 1.

5-HT2ARs increase synaptic activity in the PFC. (A1) Administration of αm-5-HT (10 μM) results in a large increase in both the frequency and amplitude of sEPSCs recorded from a layer V pyramidal neuron. (A2) Histogram depicting the effect of αm-5-HT on the distribution of sEPSC amplitudes for the experiment illustrated in A1. The leftmost distribution centered at 0 pA depicts the noise distribution. (A3) Cumulative distribution of sEPSC amplitudes recorded before and after the administration of αm-5-HT for the same experiment. (B1) In a different cell, two consecutive administrations of αm-5-HT (10 μM) result in reliable increases in sEPSC activity. (Inset) Plot summarizing the effect of consecutive applications of αm-5-HT on sEPSCs (n = 6). White bars, baseline; gray bars, αm-5-HT. (B2) Administration of MDL 100907 (300 nM) blocks the ability of αm-5-HT to elicit an increase in sEPSC activity. (Inset) Plot summarizing the effect of MDL 100907 (n = 7). (∗, P < 0.01, paired Student's t test). White bars, baseline; gray bars, αm-5-HT.