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. 1999 Jan 4;189(1):89–102. doi: 10.1084/jem.189.1.89

Table I.

Potency of Recombinant Toxins on Human and Mouse T Cells

Proliferation potential P50 [pg/ml]
Toxin Human SJL B10.M B10/J C3H BALB/c
SEA  0.1         20        12 1.8      19       1,000
SEE  0.2       10        12 1.5       50     15
SEB  0.8   7,000      80,000 5,000      10,000       1,000
TSST  0.2        20    1,000 1.2    100    10
SPE-C  0.1 >100,000 >100,000 >100,000 >100,000 >100,000
SMEZ  0.08 80      80 100        9,000        200
SMEZ-2  0.02      100       15 10    800     18
SPE-G  2 >100,000 >100,000 >100,000 >100,000 >100,000
SPE-H 50     15    800 5,000    100    1,000

Human PBLs and mouse T cells were stimulated with varying amounts of recombinant toxin. The P50 value reflects the concentration of recombinant toxin required to induce 50% maximal cell proliferaton. No proliferation was detected for rSPE-C and rSPE-G at any concentration tested on murine T cells.  

HHS Vulnerability Disclosure