Table I.

Summary of the CIA Course in FcγRIIB^−/− Mice

Mice		Incidence* (%)		Onset  ‡		Arthritic index‡		No. of arthritic paws* (%)
				(d)
Wild-type		3/43 (7.0)		50.5 ± 7.6		2.3 ± 1.9		7/172 (4.1)
FcγRIIB−/−		19/45 (42.2)		35.3 ± 12.5		6.9 ± 3.6		48/180 (26.7)
DBA/1		40/42 (95.2)		33.2 ± 8.6		8.6 ± 1.9		113/168 (67.3)

Mice were immunized with CII in CFA as described in Materials and Methods and monitored for signs of arthritis. Data are given as number and percentage of diseased mice for the incidence, as means ± SD for onset and arthritic index, and as number and percentage of arthritic paws. Arthritic indices are expressed as the maximal scores reached by each arthritic mouse during the course of CIA.  

^*Statistical analyses were performed using Fisher's test: P < 0.001 between wild-type and FcγRIIB^−/− mice, and between FcγRIIB^−/− and DBA/1 mice.  

^‡Statistical analyses were performed using Student's t test: P < 0.05 between wild-type and FcγRIIB^−/− mice; not significant between FcγRIIB^−/− and DBA/1 mice.