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. 2000 Jul 3;192(1):87–98. doi: 10.1084/jem.192.1.87

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© 2000 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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A scheme of sets of murine V_H genes and SAg reactivity. In many strains, genes from clan I and clan II are the source of most of the repertoire, whereas clan III represents a nonoverlapping set. Most clan III products interact with the Fab-binding site of SpA and also with LJ-26, a recombinant avian mAb. Each recognizes similar but nonidentical sets. These also identify S107-encoded antibodies, including those expressing the T15-specific VS107.1 rearrangement that generally display among the highest levels of SpA-binding affinity.