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. 2000 Jul 3;192(1):87–98. doi: 10.1084/jem.192.1.87

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© 2000 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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SpA or MSpA induces persistent loss of natural IgM anti-PC antibodies, whereas natural IgM anti-α1–3 dextran antibodies are nonspecifically increased. Neonatal BALB/c mice were treated with control proteins or different forms of SpA for the first 2 wk of life, and natural IgM antibody levels were quantitated 3–5 mo later. For groups of four mice, serial dilutions of antibody reactivities in ELISA are indicated with mean ± SEM.