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. 2000 Jul 3;192(1):41–52. doi: 10.1084/jem.192.1.41

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© 2000 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Intranasal administration of pCMV-TGF-β1 prevented TNBS-induced colitis in SJL/J mice. Weight changes (mean ± SD) of one experiment representative of three independent experiments is shown. Each group consists of 10 mice treated intranasally on day 0 with pCMV-TGF-β1 (100 μg/mouse). Alone, □; pCMV-TGF-β1 (100 μg intranasally) plus rectal instillation of TNBS (2.5 mg/mouse), ○; pCMV-TGF-β1 (100 μg intranasally) plus rectal instillation of TNBS (2.5 mg) and anti–IL-10 mAbs (SXC-1 and SXC-2 intraperitoneally 1 mg each/mouse), ▵; rectal instillation of TNBS alone (2.5 mg), •.