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. 2004 Jan 5;199(1):113–124. doi: 10.1084/jem.20030613

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Copyright © 2004, The Rockefeller University Press

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Figure 9. — Protection of brain from ischemia by suppression of Noxa expression. SE or AS oligonucleotides (2 μg in 1 μl) were injected into the lateral ventricle 4 h before MCA occlusion for 2 h. Brain was reperfused for 14 h, removed, and then cut into eight coronal slices. (A) Representative section stained with triphenyl tetrazolium chloride (TTC). (B) Western blot analysis of Noxa from the corresponding slices of rat brain. (C) Infarction volume was calculated after measuring the infarct areas on coronal brain sections as described in Materials and Methods. The infarction volume of the control animal (SE) was 154.24 ± 28.38 mm³, whereas that of the experimental group (AS) was reduced to 48.86 ± 13.46 mm³ (*, P < 0.05).

Figure 9. — Protection of brain from ischemia by suppression of Noxa expression. SE or AS oligonucleotides (2 μg in 1 μl) were injected into the lateral ventricle 4 h before MCA occlusion for 2 h. Brain was reperfused for 14 h, removed, and then cut into eight coronal slices. (A) Representative section stained with triphenyl tetrazolium chloride (TTC). (B) Western blot analysis of Noxa from the corresponding slices of rat brain. (C) Infarction volume was calculated after measuring the infarct areas on coronal brain sections as described in Materials and Methods. The infarction volume of the control animal (SE) was 154.24 ± 28.38 mm³, whereas that of the experimental group (AS) was reduced to 48.86 ± 13.46 mm³ (*, P < 0.05).