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. 1998 Jan 1;111(1):161–180. doi: 10.1085/jgp.111.1.161

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Protein kinase C inhibits the BLM K_ATP channel. PKC directly inhibits the BLM K_ATP channel. In this inside-out experiment, the pipette contains KCl (solution d), the bath contains NaCl (solution c) plus 0.2 mM ATP and 50 nM Ca²⁺, and the command potential is −60 mV. (A) The running average of current versus time (16-ms window) is shown. PKC (0.5 U/ml) was added to the bath where indicated. (B) Original current traces representative of channel activity during the control period (top trace) and after inhibition by PKC (bottom two traces). In this experiment, PKC produced an 89% decrease in nP _o. The all channels closed level (dashed line) and open channel levels (dotted lines) are indicated.