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. 1998 Jan 1;111(1):139–160. doi: 10.1085/jgp.111.1.139

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The K channel opener diazoxide activates the BLM K⁺ channel. Diazoxide activates the BLM K⁺ channel in the presence of ATP. In the experiment depicted, the pipette contains KCl (solution d), the bath contains NaCl (solution c), and the command potential is −80 mV. (top) A running average (window width 16 ms) of current versus time. (bottom) Sample current traces from the same experiment. With diazoxide alone, the channel opens infrequently (nP _o = 0.15) and no more than two channels are open at a time. Diazoxide combined with 0.2 mM ATP, however, promptly increases channel activity and within 5 min, up to 13 simultaneously open channels are evident (nP _o = 5.27). The all channels closed level (dashed line) and open channel levels (dotted lines) are indicated.