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. 1998 Jan 1;111(1):75–82. doi: 10.1085/jgp.111.1.75

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(A) Voltage-clamped currents from F1489Q mutant sodium channels expressed in Xenopus oocytes. Shown are macroscopic currents recorded from excised inside-out patches of membrane expressing the F1489Q α subunits and wild-type β1 subunits. The currents were elicited by voltage steps to −60, −40, −20, 0, 20, 40, 60, 80, and 110 mV from a −100 mV holding potential. (B) Current–voltage relations of F1489Q channels in oocytes. Peak currents were measured, and then plotted versus the voltage of the applied test pulse. For this patch, the largest current (107 pA) observed was elicited by a voltage step from −100 to −20 mV and the current changed direction at +75 mV.