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. 2000 Jan 1;115(1):33–50. doi: 10.1085/jgp.115.1.33

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© 2000 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Distribution of free energy perturbations in channel gating. (A) The bar graph plots the absolute value of ΔΔG ₀ for all mutations studied. Data are mean ± SEM from Table . The solid line superimposed on the |ΔΔG ₀| plot is a windowed hydrophobicity index calculated using the Kyte-Doolittle scale (Kyte and Doolittle 1982) with a 17-residue window. (B) Sliding window analysis for mean ΔΔG ₀ (black line) and hydrophobicity index (gray line). Both use a 17-residue sliding window. Letters and numbers indicate the wild-type residues and their positions, respectively.