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. 1986 Aug;124(2):310–318.

Monocytoid B-cell lymphoma. A novel B-cell neoplasm.

K Sheibani, C C Sohn, J S Burke, C D Winberg, A M Wu, H Rappaport
PMCID: PMC1888300  PMID: 3488686

Abstract

Monocytoid B lymphocytes (MBLs), originally described as part of the histologic picture of toxoplasmic lymphadenitis, have been recognized as a reactive component in a variety of lymph node disorders. The authors now report 3 cases of non-Hodgkin's lymphoma in which a multidisciplinary approach allowed them to confirm the existence of a malignant lymphoma composed of the neoplastic counterpart of the MBLs found in nonneoplastic disorders. In all 3 cases, the lymphoma was composed of a relatively monomorphous infiltrate of atypical MBLs that had rather uniform-appearing nuclei and had well-defined, moderately abundant pale cytoplasm. The pattern of lymph node involvement in all 3 cases was predominantly sinusoidal and interfollicular. The neoplastic lymphoid cells were strongly positive for B-cell-restricted antigens; the light- and heavy-chain phenotypes were kappa-IgM (2 cases) and kappa-IgG (1 case). In all 3 cases, rearrangement of heavy- and/or light-chain genes was clearly identified by Southern blot hybridization. The name "monocytoid B-cell lymphoma" is proposed for this newly described malignant B-cell neoplasm.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aisenberg A. C., Wilkes B. M. Monoclonal antibody studies in B-cell chronic lymphocytic leukemia and allied disorders. Hematol Oncol. 1983 Jan-Mar;1(1):13–19. doi: 10.1002/hon.2900010104. [DOI] [PubMed] [Google Scholar]
  2. Arnold A., Cossman J., Bakhshi A., Jaffe E. S., Waldmann T. A., Korsmeyer S. J. Immunoglobulin-gene rearrangements as unique clonal markers in human lymphoid neoplasms. N Engl J Med. 1983 Dec 29;309(26):1593–1599. doi: 10.1056/NEJM198312293092601. [DOI] [PubMed] [Google Scholar]
  3. Brunning R. D., McKenna R. W., Rosai J., Parkin J. L., Risdall R. Systemic mastocytosis. Extracutaneous manifestations. Am J Surg Pathol. 1983 Jul;7(5):425–438. doi: 10.1097/00000478-198307000-00005. [DOI] [PubMed] [Google Scholar]
  4. Burke J. S., Byrne G. E., Jr, Rappaport H. Hairy cell leukemia (leukemic reticuloendotheliosis). I. A clinical pathologic study of 21 patients. Cancer. 1974 May;33(5):1399–1410. doi: 10.1002/1097-0142(197405)33:5<1399::aid-cncr2820330526>3.0.co;2-e. [DOI] [PubMed] [Google Scholar]
  5. Cardoso De Almeida P., Harris N. L., Bhan A. K. Characterization of immature sinus histiocytes (monocytoid cells) in reactive lymph nodes by use of monoclonal antibodies. Hum Pathol. 1984 Apr;15(4):330–335. doi: 10.1016/s0046-8177(84)80030-1. [DOI] [PubMed] [Google Scholar]
  6. Cleary M. L., Chao J., Warnke R., Sklar J. Immunoglobulin gene rearrangement as a diagnostic criterion of B-cell lymphoma. Proc Natl Acad Sci U S A. 1984 Jan;81(2):593–597. doi: 10.1073/pnas.81.2.593. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Cossman J., Neckers L. M., Hsu S., Longo D., Jaffe E. S. Low-grade lymphomas. Expression of developmentally regulated B-cell antigens. Am J Pathol. 1984 Apr;115(1):117–124. [PMC free article] [PubMed] [Google Scholar]
  8. Dorfman R. F., Remington J. S. Value of lymph-node biopsy in the diagnosis of acute acquired toxoplasmosis. N Engl J Med. 1973 Oct 25;289(17):878–881. doi: 10.1056/NEJM197310252891702. [DOI] [PubMed] [Google Scholar]
  9. Epstein A. L., Marder R. J., Winter J. N., Fox R. I. Two new monoclonal antibodies (LN-1, LN-2) reactive in B5 formalin-fixed, paraffin-embedded tissues with follicular center and mantle zone human B lymphocytes and derived tumors. J Immunol. 1984 Aug;133(2):1028–1036. [PubMed] [Google Scholar]
  10. Harris N. L., Bhan A. K. Mantle-zone lymphoma. A pattern produced by lymphomas of more than one cell type. Am J Surg Pathol. 1985 Dec;9(12):872–882. [PubMed] [Google Scholar]
  11. Hsu S. M., Yang K., Jaffe E. S. Hairy cell leukemia: a B cell neoplasm with a unique antigenic phenotype. Am J Clin Pathol. 1983 Oct;80(4):421–428. doi: 10.1093/ajcp/80.4.421. [DOI] [PubMed] [Google Scholar]
  12. Jaffe E. S. Pathologic and clinical spectrum of post-thymic T-cell malignancies. Cancer Invest. 1984;2(5):413–426. doi: 10.3109/07357908409040316. [DOI] [PubMed] [Google Scholar]
  13. Miettinen M., Franssila K. Malignant lymphoma simulating lymph node toxoplasmosis. Histopathology. 1982 Mar;6(2):129–140. doi: 10.1111/j.1365-2559.1982.tb02710.x. [DOI] [PubMed] [Google Scholar]
  14. Miettinen M. Histological differential diagnosis between lymph node toxoplasmosis and other benign lymph node hyperplasias. Histopathology. 1981 Mar;5(2):205–216. doi: 10.1111/j.1365-2559.1981.tb01778.x. [DOI] [PubMed] [Google Scholar]
  15. Osborne B. M., Butler J. J., Mackay B. Sinusoidal large cell ("histiocytic") lymphoma. Cancer. 1980 Dec 1;46(11):2484–2491. doi: 10.1002/1097-0142(19801201)46:11<2484::aid-cncr2820461129>3.0.co;2-p. [DOI] [PubMed] [Google Scholar]
  16. Sheibani K., Fritz R. M., Winberg C. D., Burke J. S., Rappaport H. "Monocytoid" cells in reactive follicular hyperplasia with and without multifocal histiocytic reactions: an immunohistochemical study of 21 cases including suspected cases of toxoplasmic lymphadenitis. Am J Clin Pathol. 1984 Apr;81(4):453–458. doi: 10.1093/ajcp/81.4.453. [DOI] [PubMed] [Google Scholar]
  17. Sheibani K., Tubbs R. R., Gephardt G. N., McMahon J. T., Valenzuela R. Comparison of alternative chromogens for renal immunohistochemistry. Hum Pathol. 1981 Apr;12(4):349–354. doi: 10.1016/s0046-8177(81)80144-x. [DOI] [PubMed] [Google Scholar]
  18. Stansfeld A. G. The histological diagnosis of toxoplasmic lymphadenitis. J Clin Pathol. 1961 Nov;14(6):565–573. doi: 10.1136/jcp.14.6.565. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Stein H., Lennert K., Mason D. Y., Liangru S., Ziegler A. Immature sinus histiocytes. Their identification as a novel B-cell population. Am J Pathol. 1984 Oct;117(1):44–52. [PMC free article] [PubMed] [Google Scholar]
  20. Weisenburger D. D., Kim H., Rappaport H. Mantle-zone lymphoma: a follicular variant of intermediate lymphocytic lymphoma. Cancer. 1982 Apr 1;49(7):1429–1438. doi: 10.1002/1097-0142(19820401)49:7<1429::aid-cncr2820490720>3.0.co;2-5. [DOI] [PubMed] [Google Scholar]
  21. van den Oord J. J., de Wolf-Peeters C., De Vos R., Desmet V. J. Immature sinus histiocytosis. Light- and electron-microscopic features, immunologic phenotype, and relationship with marginal zone lymphocytes. Am J Pathol. 1985 Feb;118(2):266–277. [PMC free article] [PubMed] [Google Scholar]

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