Table 2.
Histopathological Characteristics and MSI Status of EOGC Cases
| Characteristics | Total cases | MSS | MSI | MSI-L | MSI-H | P value | P value (MSI-H versus others) |
|---|---|---|---|---|---|---|---|
| Tumor depth (n) | 104 | 70 | 34 | 28 | 6 | 0.46 | 0.35 |
| T1 | 11 | 9 | 2 | 2 | 0 | ||
| T2 | 73 | 50 | 23 | 19 | 4 | ||
| T3 | 12 | 7 | 5 | 3 | 2 | ||
| T4 | 8 | 4 | 4 | 4 | 0 | ||
| Nodal status (n) | 103 | 69 | 34 | 28 | 6 | 0.09 | 0.22 |
| N0 | 26 | 18 | 8 | 8 | 0 | ||
| N1 | 54 | 32 | 22 | 16 | 6 | ||
| N2 | 16 | 15 | 1 | 1 | 0 | ||
| N3 | 7 | 4 | 3 | 3 | 0 | ||
| Tumor grade (n) | 136 | 96 | 40 | 33 | 7 | 0.09 | 0.007 |
| Well/G1 | 8 | 5 | 3 | 1 | 2 | ||
| Moderate/G2 | 16 | 12 | 4 | 4 | 0 | ||
| Poor/G3 | 78 | 57 | 21 | 20 | 1 | ||
| Anaplastic/G4 | 5 | 3 | 2 | 1 | 1 | ||
| Mixed* | 29 | 19 | 10 | 7 | 3 | ||
| Carneiro type (n) | 139 | 98 | 41 | 34 | 7 | 0.56 | 0.32 |
| Isolated cell | 54 | 42 | 12 | 9 | 3 | ||
| Glandular | 37 | 26 | 11 | 9 | 2 | ||
| Mixed* | 43 | 26 | 17 | 15 | 2 | ||
| Solid | 5 | 4 | 1 | 1 | 0 | ||
| Goseki type (n) | 122 | 86 | 36 | 30 | 6 | n.s. | n.s. |
| I | 25 | 19 | 6 | 5 | 1 | ||
| II | 17 | 10 | 7 | 7 | 0 | ||
| III | 32 | 22 | 10 | 9 | 1 | ||
| IV | 43 | 32 | 11 | 7 | 4 | ||
| Mixed* | 5 | 3 | 2 | 2 | 0 | ||
| Lauren type (n) | 135 | 95 | 41 | 34 | 7 | 0.006 | 0.05 |
| Diffuse | 81 | 62 | 19 | 16 | 3 | ||
| Intestinal | 47 | 32 | 15 | 13 | 2 | ||
| Atypical | 7 | 1 | 6 | 4 | 2 | ||
| Ming type (n) | 101 | 67 | 34 | 28 | 6 | 0.19 | 0.33 |
| Expanding | 20 | 10 | 10 | 8 | 2 | ||
| Infiltrating | 81 | 57 | 24 | 20 | 4 | ||
| WHO type (n) | 139 | 98 | 41 | 34 | 7 | 0.21 | n.s. |
| Tubular | 79 | 53 | 26 | 22 | 4 | ||
| Signet | 28 | 24 | 4 | 3 | 1 | ||
| Mucinous | 15 | 11 | 4 | 3 | 1 | ||
| Undifferentiated | 7 | 4 | 3 | 3 | 0 | ||
| Tubulopapillary | 4 | 1 | 3 | 3 | 0 | ||
| Adenosquamous | 1 | 1 | 0 | 0 | 0 |
*
Mixed, more than one type of morphology (grade, Carneiro, Goseki, and Ming type) seen where at least 25% of the second (or third) morphological entity is found in the tumor population.
n.s., nonsignificant P value > 0.05. WHO, World Health Organization.