TABLE II. LOCATION OF ASPARTIC ACID MUTATIONS IN COMP.
| Domain | Number of Mutations | Aspartic Acid | Codon GAC |
|---|---|---|---|
| Total | 66 | 41(62%)a | 39 (95%)b |
| Type-3 repeats | |||
| -Hybrid | 1 | 1 | 1 |
| -Calmodulin-like | |||
| CR 1 | 4 | 0 | |
| CR 2 | 2 | 2 | 2 |
| CR 3 | 7 | 4 | 4 |
| CR 4 | 1 | 1 | 1 |
| CR 5 | 9 | 2 | 2 |
| CR 6 | 29 | 25 | 25 |
| CR 7 | 9 | 6 | 4 |
| COOH | 4 | 0 |
a
percentage of total mutations;
b
GAC percentage of total possible (GAC, GAT) codons for aspartic acid;
GAC, codon for Asp; COOH, globular carboxyl domain. See Figure 1 identifying location of aspartic acid mutations in the Type-3 repeats.