Table 1.
Embryonic lethality in UbC−/− mice
| Age | Litters | UbC+/+ | UbC+/− | UbC−/− | Dead | Total |
|---|---|---|---|---|---|---|
| E9.5–11.5 | 4 | 10 | 19 | 7 | 0 | 36 |
| E12.5 | 17 | 46 | 66 | 20 | 21 | 153 |
| E13.5 | 26 | 21 | 51 | 11 | 21 | 104 |
| E14.5–15.5 | 7 | 18 | 29 | 2 | 13 | 62 |
| E16.5–17.5 | 5 | 9 | 21 | 0 | 8 | 38 |
| E18.5 | 2 | 3 | 9 | 0 | 1 | 13 |
| Birth | 52 | 95 | 196 | 0 | 0 | 291 |
| Embryos were dissected at the indicated time of gestation and examined heartbeat for viability. Genotypes were determined by PCR using genomic DNA isolated from embryos. E: embryonic day. | ||||||