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. 2007 May 17;26(11):2777–2785. doi: 10.1038/sj.emboj.7601726

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Copyright © 2007, European Molecular Biology Organization

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PG14 PrP does not suppress white matter pathology in the cerebellum of Tg(F35) mice. Paraffin sections stained with hematoxylin and eosin (A, C, E, G) and semithin plastic sections stained with toluidine blue (B, D, F, H) were prepared from the cerebella of 72-day-old mice of the following genotypes: F35^+/0 Prn-p^0/0 (A, B); F35^+/0 PG14-A2^+/0 Prn-p^0/0 (C, D); F35^+/0 Prn-p^+/0 (E, F); PG14-A2^+/0 Prn-p^0/0 (G, H). The semithin sections were taken from the cerebellar white matter. White matter vacuolation is present to a similar extent in F35^+/0 Prn-p^0/0 mice (A, B) and F35^+/0 PG14-A2^+/0 Prn-p^0/0 mice (C, D). Scale bar in (A) (applicable to C, E, G)=500 μm. Scale bar in (B) (applicable to D, F, H)=100 μm.