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Hypothetical rearrangement of βC domains upon binding of B knobs in a way that allows the βC-βC (bb) interaction shown in Fig. 3b. As shown in the upper panel, the lateral association between γC domains (taken directly from the packing observed in DD-BO) positions the βC domains such that only a small shift is needed for a bb interaction, perhaps as a result of binding B knobs. A concomitant opening up of the region between βC domain and coiled coils occurs as a consequence.
