Table 1.

Clinical data and EGFR status among primary CRC and their related metastases

Clinical data						EGFR statusa on tissue sections
Case no.	Sex	Age (years)	pTNM	Location	Neoadjuvant treatment	Primary site	Synchronous metastases (location number)				Metachronous metastases (location number)
							1	2	3	4	1	2	3	4	5
1	M	60	T3N1M1	C		+	+	+	+	+
2	M	60	T3N2M1	R	RCT	+	+	+	+
3	M	66	T2N0M1	R		+	+	+	+
4	M	49	T3N2M1	R	CT	+	+	+			+	+	+	+	+
5	M	70	T3N1M1	C		+	+	+
6	F	74	T3N1M1	R	RCT	+	+	+
7	F	59	T3N2M1	R	CT	+	+	+			−
8	M	71	T3N2M1	C		+	+	+
9	F	55	T3N2M1	R		−	+	−
10	F	61	T4N1M1	C	CT	+	+				+
11	F	68	T3N1M1	C	CT	+	+				+
12	M	75	T3N1M1	R		+	+
13	M	72	T3N1M1	C		+	+
14	M	54	T3N0M1	C		+	+
15	F	55	T4N1M1	C		+	+
16	F	57	T4N2M1	C		+	+
17	F	52	T3N1M1	R		+	+
18	M	53	T3N0M1	C		+	+
19	M	62	T4N2M1	C		+	+
20	F	77	T3N2M1	C		+	+
21	F	49	T3N1M1	C		+	+
22	F	51	T3N2M1	C		+	+
23	M	62	T3N2M1	R	RT	+	+
24	F	65	T3N1M1	C	CT	+	+
25	M	56	T4N1M1	C	CT	+	+
26	F	47	T3N1M1	R	RT	+	+
27	F	59	T3N1M1	C		+	−
28	F	45	T3N2M1	C		+	−
29	F	81	T3N1M1	R		−	+
30	M	58	T2N0M1	C		−	+
31	M	69	T3N1M1	C		−	+
32	F	68	T3N2M1	C		−	+

Liver metastases in all cases except for a metachronous pulmonary metastasis and a synchronous ovarian metastasis in patients 7 and 15, respectively

C colon, R rectum, RCT radio-chemotherapy, CT chemotherapy before surgical resection of metastasis, RT radiotherapy

^aPositive if >1% of tumor cells expressed EGFR