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Classical Hodgkin lymphoma vs. anaplastic large cell lymphoma: cHL with portal infiltrates of Hodgkin and Reed-Sternberg HRS cells (arrows) in a background rich in eosinophils (a). The HRS cells strongly express CD30 (b) and the EBV encoded latent membrane protein 1 (LMP1) (c). Anaplastic large cell lymphoma (ALCL) with portal infiltrates of pleomorphic large cells resembling HRS cells (arrows) (d) and strong positivity for CD30 (e) and the cytotoxic molecule perforin (f)
