Time course of polyP-dependent AMP phosphorylation. The
reaction mixtures (100 μl) containing 50 mM Tris⋅HCl (pH
8.0), 50 mM ammonium sulfate, 10 mM MgCl2, 5 mM AMP, polyP
(75 mM of phosphate, chain length, 15–20), 4 μg purified PPK, and a
cell lysate (0.8 μg of proteins) was incubated at 30°C. The ADP and
ATP formed were monitored and plotted as the sum of both levels.
■, No lysate; ⧫, the cell lysate of JM109 harboring the
control vector pTrc99A; ●, the cell lysate of
JM109 overproducing ADK.