Schematic diagram of the HRSV F protein sequence. F1 and F2 are formed
after proteolytic cleavage of the precursor F0. The signal peptide
(SP), the cleavage site (CS), the putative fusion peptide (FP), the
N-terminal HR (HR-N) region, the C-terminal HR (HR-C) region, and the
transmembrane segment (TM) within the amino acid sequence of the
recombinant recRSV-1 construct are indicated. The HR-N and HR-C regions
predicted by learncoil-vmf are represented by shaded boxes.
Protease-resistant fragments from trypsin (HRSV-N57 and HRSV-C45) and
proteinase K (HRSV-N51 and HRSV-C39) cleavage are indicated.