Figure 6.

The cavity on the surface of the HRSV-N57 coiled coil. (A) A stereo view of interactions in the HRSV-N57 cavity. Two phenylalanine residues of HRSV-C45 (yellow) fit into the cavity formed by two neighboring HRSV-N57 peptides (blue). A prime symbol is used to distinguish residues from the two HRSV-N57 chains. Figure was prepared with molscript (45). (B) Comparison of cavity interactions of the HRSV and SV5 structures. The HRSV-N57 coiled coils, which superimpose closely with the SV5 N peptide coiled coils (21), are represented as a molecular surface (the most convex part shown in green and the most concave in gray). The HRSV-C45 (yellow) and SV5 C peptide (pink) helices are shown as ribbons with selected side chains that pack into the cavity. The relative shift of the C peptides is clearly visible. Figure was drawn with the program grasp (46).