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Hydrolytic editing cycle involving four acyl enzyme intermediates progressively on HMWP1. Two acyl-O-Ser intermediates on the AT and TE domains (generated in steps 1 and 4 and two acyl-S-phosphopantetheinyl-carrier protein intermediates in the ACP and PCP3 domains (generated in steps 2 and 3) are shown. The catalytic hydrolysis by water occurs in the TE active site shown in step 5.
