Skip to main content
. Author manuscript; available in PMC: 2008 Mar 1.
Published in final edited form as: Neuropharmacology. 2006 Dec 5;52(3):925–930. doi: 10.1016/j.neuropharm.2006.10.010

Fig. 2.

Fig. 2

A. Rats were injected with either icilin or vehicle after the 0 min collection. At 15 min, 0.50 mg/kg icilin (■) increased glutamate levels significantly compared to icilin rats pretreated with nalfurafine (▲) or controls [saline (sal)/vehicle (veh) (●) or nalfurafine (nalfur)/veh (▼)] as well as pretreatment levels (**p<0.01; two-way ANOVA followed by Bonferroni post hoc test). B. Area under the curve (AUC) was analyzed for the first 60 min (15-60 min) following icilin and confirmed inhibition of icilin-evoked glutamate release by nalfurafine (**p< 0.01; one way ANOVA followed by Newman Keuls post-hoc test). Nalfurafine had no effect on glutamate levels compared to pretreatment glutamate levels or saline/vehicle.