Table 4.
Reports of positive selection pressure on CT genes
| CT_family | Gene name | Human RefSeq | Reference | Present work# |
| CT1 | MAGEA4 | NM_002362 | I | Yes |
| CT1 | MAGEA5 | NM_021049 | I | Yes |
| CT1 | MAGEA10 | NM_021048 | I | Yes |
| CT2 | BAGE2 | NM_182482 | I | |
| CT3 | MAGEB2 | NM_002364 | I | Yes |
| CT3 | MAGEB3 | NM_002365 | I | Yes |
| CT5 | SSX1 | NM_005635 | I, III | Yes |
| CT5 | SSX8 | NM_174961 | I, III | Yes |
| CT7 | MAGEC2 | NM_016249 | I | |
| CT7 | MAGEC3 | NM_138702 | I | |
| CT11 | SPANX-N2 | NM_001009615 | III | |
| CT11 | SPANX-N3 | NM_001009609 | III | |
| CT11 | SPANX-N4 | NM_001009613 | III | |
| CT11 | SPANX-N5 | NM_001009616 | III | |
| CT11 | SPANXA | NM_013453 | III | |
| CT11 | SPANXB | NM_032461 | III | |
| CT11 | SPANXC | NM_022661 | III | |
| CT14 | SAGE1 | NM_018666 | I, II | Yes |
| CT16 | PAGE1 | NM_003785 | I | Yes |
| CT37 | FMR1NB | NM_152578 | I | Yes |
| CT38 | FTHL17 | NM_031894 | I | Yes |
| CT48 | SLCO6A1 | NM_173488 | I | |
| CT55 | CXorf48 | NM_017863 | I | |
| CT56 | THEG | NM_016585 | I | Yes |
| CT63 | PASD1 | NM_173493 | I | |
| CT65 | TULP2 | NM_003323 | I | Yes |
| CT77 | CPXCR1 | NM_033048 | I | Yes |
| CT80 | PIWIL2 | NM_018068 | I | |
| CTNA | PRAME | NM_006115 | I | Yes |
| CTNA | PRAME | cluster on chromosome 1 | IV | Yes |
Positive selection pressure on CT genes, from analysis of human and chimpanzee sequences, reported in: I, as defined by dN/dS > 1 [18, 33]. II, as defined by likelihood ratio test with p-value < 0.05 [35]. III, as defined by dN/dS > 1 [27] IV, inferred from dN/dS > 1 and sites modelling on human alignments [28] # Confirmed 16 previously reported positively selected CT genes, plus an additional 18 positively selected CT genes (see Table 2).