Table 2.
Properties of destabilizing regions detected in the dataset proteins.
| Pdb ida | N Regb | N resc | F resd | ASAe | F ASAf | Cleftg |
| 1c7k | 1 | 7 | 5.3 | 196 | 3.0 | F |
| 1e1a | 1 | 9 | 2.9 | 331 | 2.5 | T |
| 1 | 10 | 3.2 | 290 | 2.2 | F | |
| 1 | 19 | 6.1 | 256 | 1.9 | F | |
| 1e3f | 1 | 18 | 3.9 | 170 | 0.9 | T |
| 1e5t | 1 | 18 | 2.5 | 450 | 1.6 | T |
| 1 | 11 | 1.5 | 405 | 1.4 | T | |
| 1 | 4 | 0.6 | 143 | 0.5 | T | |
| 1e6l | 1 | 6 | 4.7 | 410 | 6.2 | T |
| 1ea7 | 1 | 4 | 1.3 | 207 | 1.9 | T |
| 1 | 17 | 5.5 | 495 | 4.5 | F | |
| 1 | 7 | 2.3 | 546 | 4.9 | F | |
| 1 | 9 | 2.9 | 82 | 0.7 | F | |
| 1 | 4 | 1.3 | 196 | 1.8 | T | |
| 1f2x | 1 | 4 | 1.6 | 230 | 2.0 | F |
| 1gcp | 1 | 10 | 14.9 | 644 | 15.2 | F |
| 1gkb | 4 | 22 | 9.3 | 152 | 2.0 | F |
| 1gqv | 1 | 8 | 5.9 | 573 | 7.4 | F |
| 1gt9 | 1 | 8 | 2.2 | 309 | 2.3 | F |
| 1 | 10 | 2.8 | 114 | 0.9 | F | |
| 1 | 10 | 2.8 | 534 | 4.0 | F | |
| 1gu7 | 2 | 6 | 1.6 | 434 | 2.8 | T |
| 2 | 11 | 3.0 | 465 | 3.0 | T | |
| 1gud | 1 | 6 | 2.1 | 422 | 3.2 | F |
| 1 | 20 | 6.9 | 571 | 4.4 | T | |
| 1 | 4 | 1.4 | 289 | 2.2 | T | |
| 1 | 6 | 2.1 | 234 | 1.8 | F | |
| 1gus | 4 | 13 | 12.9 | 262 | 7.6 | T |
| 1gxy | 1 | 12 | 5.4 | 107 | 1.0 | T |
| 1 | 6 | 2.7 | 386 | 3.5 | T | |
| 1h1y | 1 | 12 | 2.7 | 546 | 3.3 | T |
| 2 | 9 | 4.1 | 179 | 2.2 | T | |
| 1h6l | 1 | 21 | 5.9 | 493 | 3.5 | F |
| 1 | 4 | 1.1 | 195 | 1.4 | T | |
| 1hf8 | 2 | 5 | 1.9 | 425 | 3.6 | F |
| 2 | 18 | 6.8 | 816 | 6.8 | T | |
| 1hhq | 6 | 7 | 4.7 | 114 | 1.8 | F |
| 6 | 13 | 8.7 | 748 | 12.6 | T | |
| 1is5 | 4 | 4 | 3.0 | 185 | 3.2 | T |
| 1jcf | 1 | 14 | 4.2 | 553 | 3.8 | T |
| 1 | 5 | 1.5 | 256 | 1.7 | F | |
| 1 | 19 | 5.7 | 316 | 2.2 | F | |
| 1 | 8 | 2.4 | 662 | 4.5 | T | |
| 1kl4 | 4 | 5 | 4.2 | 429 | 8.4 | T |
| 1mix | 1 | 11 | 5.3 | 705 | 5.5 | T |
| 1 | 6 | 2.9 | 408 | 3.2 | F | |
| 1 | 4 | 1.9 | 304 | 2.4 | T | |
| 1nof | 1 | 25 | 6.5 | 587 | 4.0 | F |
| 1 | 6 | 1.6 | 255 | 1.7 | F | |
| 1 | 6 | 1.6 | 415 | 2.8 | F | |
| 1 | 6 | 1.6 | 144 | 1.0 | F | |
| 1o6v | 1 | 11 | 2.4 | 376 | 1.9 | F |
| 1 | 11 | 2.4 | 679 | 3.5 | F | |
| 1 | 13 | 2.8 | 608 | 3.1 | F | |
| 1 | 5 | 1.1 | 315 | 1.6 | F | |
| 1o7i | 1 | 4 | 3.5 | 346 | 5.1 | T |
| 1o88 | 1 | 7 | 2.0 | 198 | 1.5 | T |
| 1 | 5 | 1.4 | 296 | 2.2 | F | |
| 1 | 7 | 2.0 | 313 | 2.3 | F | |
| 1 | 4 | 1.1 | 211 | 1.6 | F | |
| 1 | 4 | 1.1 | 248 | 1.8 | F | |
| 1 | 7 | 2.0 | 190 | 1.4 | T | |
| 1ob0 | 1 | 6 | 1.2 | 314 | 1.8 | F |
| 1 | 7 | 1.5 | 226 | 1.3 | T | |
| 1 | 4 | 0.8 | 138 | 0.8 | F | |
| 1 | 7 | 1.5 | 93 | 0.5 | T | |
| 1obq | 1 | 4 | 1.1 | 217 | 1.3 | T |
| 1 | 15 | 4.2 | 318 | 1.9 | T | |
| 1odl | 3 | 10 | 2.1 | 547 | 3.6 | F |
| 6 | 12 | 5.1 | 276 | 3.6 | T | |
| 3 | 23 | 4.9 | 54 | 0.3 | T | |
| 1oes | 1 | 6 | 2.1 | 97 | 0.7 | F |
| 1 | 5 | 1.8 | 105 | 0.8 | T | |
| 1 | 7 | 2.5 | 377 | 2.8 | T | |
| 1 | 9 | 3.2 | 423 | 3.1 | F | |
| 1ofn | 2 | 11 | 5.4 | 395 | 4.8 | T |
| 2 | 9 | 4.4 | 324 | 3.8 | T | |
| 1ogb | 1 | 11 | 1.1 | 455 | 1.2 | F |
| 1 | 15 | 1.5 | 149 | 0.4 | F | |
| 2 | 14 | 2.8 | 765 | 4.0 | F | |
| 2 | 4 | 0.8 | 236 | 1.2 | F | |
| 1oid | 1 | 4 | 0.8 | 291 | 1.3 | F |
| 1 | 17 | 3.3 | 438 | 2.0 | F | |
| 1 | 14 | 2.7 | 641 | 2.9 | F | |
| 1 | 20 | 3.8 | 504 | 2.3 | T | |
| 1 | 5 | 1.0 | 325 | 1.5 | F | |
| 1okb | 1 | 4 | 1.8 | 300 | 2.9 | F |
| 1 | 14 | 6.3 | 704 | 6.9 | T | |
| 1 | 6 | 2.7 | 329 | 3.2 | T | |
| 1qhz | 1 | 24 | 7.9 | 328 | 2.9 | T |
| 1 | 5 | 1.7 | 170 | 1.5 | F | |
| 1qjv | 1 | 5 | 1.5 | 359 | 2.4 | T |
| 1 | 33 | 9.6 | 1164 | 7.9 | F | |
| 1 | 7 | 2.0 | 165 | 1.1 | T | |
| 1qmd | 1 | 6 | 1.6 | 129 | 0.8 | T |
| 1 | 4 | 1.1 | 319 | 2.0 | T | |
| 1 | 6 | 1.6 | 417 | 2.6 | F | |
| 1 | 21 | 5.7 | 828 | 5.2 | T | |
| 1tm2 | 1 | 4 | 1.3 | 330 | 2.4 | F |
| 1 | 22 | 7.0 | 663 | 4.9 | T | |
| 1umv | 2 | 5 | 4.1 | 233 | 3.6 | T |
| 1uns | 1 | 4 | 1.7 | 246 | 2.1 | T |
| 1 | 7 | 3.0 | 262 | 2.2 | F | |
| 1uol | 1 | 7 | 3.6 | 368 | 3.7 | F |
| 1uq4 | 1 | 5 | 1.9 | 251 | 1.9 | T |
| 1usg | 1 | 30 | 4.3 | 715 | 2.7 | T |
| 2 | 13 | 3.8 | 340 | 2.6 | T | |
| 1usl | 2 | 8 | 5.1 | 304 | 4.8 | F |
| 1uuq | 1 | 13 | 3.2 | 50 | 0.3 | F |
| 1 | 5 | 1.2 | 53 | 0.3 | T | |
| 1 | 6 | 1.5 | 182 | 1.2 | F | |
| 1 | 11 | 2.7 | 356 | 2.3 | F | |
| 1w0n | 1 | 10 | 8.3 | 455 | 7.9 | F |
| 1w1h | 1 | 7 | 4.6 | 431 | 4.8 | T |
| 1w2i | 2 | 13 | 14.4 | 750 | 16.6 | T |
| 1w37 | 8 | 7 | 4.8 | 131 | 2.4 | F |
| 8 | 8 | 5.5 | 83 | 1.6 | F | |
| 1w6z | 1 | 14 | 10.9 | 592 | 9.0 | F |
| 1y2t | 1 | 8 | 1.4 | 274 | 1.3 | T |
| 2 | 8 | 2.8 | 1 | 0.0 | F | |
| 4 | 10 | 7.0 | 415 | 7.6 | T |
a Pdb identifier of structure used for energy calculations.
b Number of equivalent destabilizing regions identified in the structure (relevant for multimers only).
c Number of residues in destabilizing region.
d Fraction of protein residues in destabilizing region (in %).
e Total ASA of destabilizing region residues.
f Fraction of protein ASA in destabilizing region (in %).
g True (T) if destabilizing region sits in a cleft, False (F) otherwise.