Table 4.

Overlap between destabilizing regions and binding sites according to ligand type

Ligand type	Nu	Po	Pr	Pe	Sm	Me	Li	Total
Sig. Overlap	1 (5.7)	8 (6.2)	7 (9.6)	5 (5.7)	19 (13.6)	5 (4.5)	2 (1.7)	47
No. Overlap	9 (4.3)	3 (4.8)	10 (7.4)	5 (4.3)	5 (10.4)	3 (3.5)	1 (1.3)	36
Total	10	11	17	10	24	8	3	83

Contingency table used to perform a Fisher exact test of homogeneity, among different categories of binding sites (based on ligand types), of the fraction of statistically significant overlaps (i.e. P-value ≤ 0.05, see Methods for meaning of the P-value) between destabilizing regions and known binding sites. Abbreviations used: Nu, nucleic-acid; Po, polysaccharide; Pr, protein; Pe, peptide; Sm, small compound; Me, metal ion; Li, lipid; Sig. Overlap, statistically significant overlap; No. Overlap, statistically non-significant or absent overlap. Calculated expected numbers of statistically significant overlaps are given between brackets, below the corresponding observed numbers.