Table 3.

Plasma insulin, glucose and HOMA-IR index in rats exposed to diets of differing composition in utero.

					Maternal diet group
			Control	LPA	LPE	LPM	LPL
	Sex	Age
Insulin	M	1	1.30±0.28	1.30±0.65	0.82±0.08	1.96±1.19	0.69±0.07
(ng/ml)		9	1.55±0.51	1.68±0.91	2.54±0.81	3.33±1.84	1.41±0.75
		18	1.03±0.14	1.80±0.23*	1.98±0.29*	1.36±0.07	1.88±0.33*
	F	1	1.81±0.57	0.45±0.14	0.76±0.17	2.11±0.69	0.99±0.26
		9	1.64±1.52	1.50±1.20	2.11±0.60	2.21±0.79	1.80±0.45
		18	1.10±0.11	1.66±0.20	1.54±0.23	1.36±0.35	1.64±0.21*
Glucose	M	1	10.35±0.78	9.90±0.51	9.52±0.65	11.19±0.90	8.86±0.57
(ngmmol/L)		9	10.75±1.25	12.07±1.47	13.70±1.76†	14.05±1.39	13.02±0.95†
		18	8.71±0.45	9.92±0.84	10.59±0.96	9.83±0.80	10.93±0.90†
	F	1	11.56±0.95	8.47±0.50	9.63±0.63	9.44±0.65	9.08±0.74
		9	11.44±1.27	12.21±1.91†	14.27±1.62†	14.13±1.17†	11.31±2.16
		18	9.49±0.71	10.62±0.44	9.65±0.64	9.70±0.72	11.62±0.51
HOMA-IR	M	1	0.66±0.17	0.60±0.30	0.33±0.06	1.08±0.68	0.28±0.04
Index		9	0.52±0.33	0.25±0.08	0.42±0.31	0.33±0.10	0.16±0.06
		18	0.41±0.07	0.73±0.08	0.94±0.29	0.63±0.05	0.95±0.16
	F	1	0.93±0.30	0.17±0.06	0.28±0.09	1.00±0.37	0.43±0.14
		9	0.06±0.01	0.13±0.02	0.32±0.07	0.29±0.07	0.49±0.34
		18	0.48±0.11	0.75±0.09	0.68±0.11	0.61±0.19	0.85±0.11

All data are shown as mean ± SEM for 5-10 observations per group. ANOVA indicated that insulin concentration was influenced by maternal diet (P=0.022), the interaction of sex and age (P=0.043) and the interaction of maternal diet, age and sex (P=0.034). Glucose was influenced by age (P<0.001). Posthoc testing was performed only for univariate effects of age and maternal diet.

^*indicates significantly different to control of same age and sex (P<0.05).

^†indicates significantly different to 1 month old of same sex and maternal diet (P<0.05).