Table 4.
Plasma cholesterol, triglycerides and hepatic lipid concentrations in rats exposed to diets of differing composition in utero.
| Maternal diet group |
|||||||
|---|---|---|---|---|---|---|---|
| Control |
LPA |
LPE |
LPM |
LPL |
|||
| Sex | Age | ||||||
| Triglycerides | M | 1 | 0.95±0.09 | 0.70±0.11 | 0.60±0.09* | 0.78±0.09 | 0.74±0.10 |
| (mmol/L) | 9 | 2.79±0.37† | 2.87±0.50† | 2.25±0.62† | 3.08±1.03† | 3.36±0.74† | |
| 18 | 2.63±0.92† | 3.25±0.93† | 9.70±3.17†* | 5.70±2.45† | 8.38±2.35†* | ||
| F | 1 | 0.67±0.06 | 0.65±0.09 | 0.74±0.17 | 0.63±0.09 | 0.65±0.07 | |
| 9 | 2.15±0.30† | 2.32±0.30† | 1.68±0.24† | 2.44±0.98† | 1.89±0.46† | ||
| 18 | 2.84±0.87† | 11.35±3.30†* | 9.15±3.80†* | 13.27±2.87†* | 6.04±2.04† | ||
| Tot. cholesterol | M | 1 | 1.95±0.12 | 2.01±0.17 | 1.98±0.27 | 2.15±0.11 | 2.25±0.07 |
| (mmol/L) | 9 | 3.18±0.31† | 4.22±0.58† | 3.46±0.56 | 3.14±0.28 | 3.68±0.66† | |
| 18 | 4.88±0.77† | 7.26±1.01† | 5.53±0.97† | 7.46±1.05† | 7.96±0.79†* | ||
| F | 1 | 2.18±0.11 | 2.52±0.19 | 1.79±0.35 | 2.28±0.06 | 2.17±0.13 | |
| 9 | 2.59±0.22 | 2.78±0.25 | 2.91±0.19 | 3.16±0.34 | 2.81±0.29 | ||
| 18 | 3.66±0.56† | 6.40±0.91†* | 6.40±1.55†* | 4.56±0.76† | 4.26±0.81† | ||
| Hepatic | 1 | 2.04±0.07 | 2.21±0.30 | 2.36±0.44 | 1.96±0.34 | 1.72±0.25 | |
| Triglycerides | 9 | 17.44±3.43† | 19.31±5.13† | 15.47±1.58† | 20.25±4.44† | 15.80±2.42† | |
| (mg/total liver) | 18 | 14.18±2.73† | 41.91±1.95*† | 40.96±5.50*† | 38.23±7.48*† | 38.45±8.64*† |
Data for cholesterol and triglycerides are shown as mean ± SEM for 5-10 observations per group. Hepatic triglyceride data represent combined samples from males and females n=3 per group. ANOVA indicated that plasma triglyceride concentration was influenced by maternal diet (P<0.001), age (P<0.001) the interaction of sex and age (P<0.001), maternal diet and age (P<0.001) and the interaction of maternal diet, age and sex (P=0.029). Total cholesterol was influenced by sex (P<0.001), age (P<0.001), maternal diet (P=0.037) and the interaction of age and sex (P<0.001). Hepatic triglyceride content was influenced by maternal diet (P=0.035), age (P<0.001) and the interaction of maternal diet and age (P=0.017). Posthoc testing was performed only for univariate effects of age and maternal diet.
indicates significantly different to control of same age and sex (P<0.05).
indicates significantly different to 1 month old of same sex and maternal diet (P<0.05).