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. 1995 May;69(5):3237–3239. doi: 10.1128/jvi.69.5.3237-3239.1995

Echovirus 1 interaction with the isolated VLA-2 I domain.

S L King 1, J A Cunningham 1, R W Finberg 1, J M Bergelson 1
PMCID: PMC189033  PMID: 7535868

Abstract

The isolated I domain of the integrin VLA-2, produced as a bacterial fusion protein, specifically bound echovirus 1 and prevented virus attachment to cells. These results demonstrate that the receptor structures critical for virus attachment are contained solely within the VLA-2 I domain and that soluble receptor fragments are capable of preventing infection.

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Selected References

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