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. 2006 Jul 27;576(Pt 2):477–492. doi: 10.1113/jphysiol.2006.113068

Figure 3. Wide-field illumination of BBS-mGluR8a resulted in a loss of ICa modulation without disrupting membrane integrity.

Figure 3

A, the effect of 3 or 6 min illumination on normalized prepulse ICa in the absence or presence of FL–BTX labelling in BBS–mGluR8a-expressing neurons. ICa was normalized to the current before illumination. B, the effect of 3 min illumination on the holding current at −80 mV. The change of the holding current was calculated as the difference of the holding current before and after illumination. C, the effect of 3 or 6 min illumination on l-AP4 (1 μm) induced prepulse ICa inhibition in the absence or presence of FL–BTX labelling. The agonist-induced prepulse ICa inhibition was normalized to the inhibition before illumination. D, the effect of illumination on facilitation ratio in the absence or presence of FL–BTX labelling. The open and filled bars indicate the parameters in the absence or presence of FL–BTX labelling, respectively. *P < 0.05, ***P < 0.001 compared with non-labelled neurons.