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. 2006 Oct 5;577(Pt 3):1009–1020. doi: 10.1113/jphysiol.2006.121558

Figure 6. Ganglionic blockade with hexamethonium in WKY and SHR animals.

Figure 6

A, hexamethonium treatment reduced baseline blood pressure in both WKY and SHR rats. The magnitude of this reduction was greater in SHR rats. B, hexamethonium treatment abolished the pressor response to static muscle contraction in both animal groups. C, in WKY and SHR rats, hexamethonium treatment significantly reduced the ratio between the decrease in HR and the increase in MAP evoked by phenylephrine administration validating the effectiveness of the ganglionic block. *P < 0.05 compared to WKY rats. †P < 0.05 compared to before administration of hexamethonium.