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Three types of ICC classified by their ultrastructural features
| ICC type | Basal lamina | Caveolae | Gap junctions | Intermediate filaments | Mitochondria | Nerve contacts |
|---|---|---|---|---|---|---|
| Type 1 ICC | − | +/− | ++ | ++ | ++ | ++ |
| (least like smooth muscle cells) | ||||||
| Type 2 ICC | +/− | ++ | ++ | ++ | ++ | ++ |
| (intermediate type) | ||||||
| Type 3 ICC | ++ | ++ | ++ | ++ | ++ | ++ |
| (most like smooth muscle cells) | ||||||
Abundance, (++) present or numerous; (+/−), fuzzy or few; (−) absent. All types of ICC are positive for Kit immunoreactivity.
