Table 1.

Quantitative characteristics of mechano-electrical transduction

		Adaptation
Genotype	Maximal current (pA)*	τfast (ms)**	τslow (ms)**	No of cells/animal
Myo15sh2/sh2	226 ± 41 (124–439)	2.07 ± 0.25 (1.23–3.42)	20.5 ± 3.0 (11.9–33.1)	7/4
Myo15+/sh2	264 ± 32 (161–384)	2.10 ± 0.33 (1.15–3.65)	24.3 ± 3.4 (11.6–34.6)	7/3
Myo15+/+	228 ± 36 (125–288)	2.06 ± 0.21 (1.62–2.55)	22.1 ± 6.0 (11.3–36.0)	4/3
Whrnwi/wi	256 ± 79 (105–469)	2.00 ± 0.29 (1.30–2.54)	24.2 ± 2.7 (19.4–31.6)	5/2

The data are shown as mean ±s.e.m. (Min–Max). There were no statistically significant differences (P > 0.05, two-sided Student's t test) in these parameters among any pairs of the genotype groups.

^*Maximal mechanotransduction current was defined as a peak current evoked by the largest deflection (∼1 μm) of the stereocilia bundle at the holding potential of −90 mV.

^**Time constants were determined from the double-exponential fit of the decay of the transduction current at a displacement corresponding to half-maximal activation of this current.