Table 2.
Effect of Ih on resting membrane potential, action potentials and rebound depolarization in the AVCN, MNTB and LSO
| Vrest (mV) | AVCN | MNTB | LSO |
|---|---|---|---|
| Slowτ/lowA | −58.8 ± 1.7 | −65.3 ± 0.8 | −67.1 ± 0.2‡ |
| Slowτ/highA | −57.7 ± 1.7† | −61.7 ± 0.2† | −65.7 ± 0.4‡ |
| Fastτ/lowA | −56.1 ± 1.7‡ | −63.5 ± 0.6‡ | −64.6 ± 0.5‡ |
| Fastτ/highA | −53.7 ± 1.4‡ | −61.4 ± 0.5‡ | −61.3 ± 0.8 |
| AP amplitude (mV) | |||
| Slowτ/lowA | 62.8 ± 5.3 | 61.5 ± 4.1 | 99.8 ± 4.2† |
| Slowτ/highA | 62.5 ± 5.5 | 60.3 ± 4.0† | 96.5 ± 3.4† |
| Fastτ/lowA | 58.7 ± 5.5† | 57.8 ± 2.9 | 91.2 ± 3.7 |
| Fastτ/highA | 57.5 ± 5.9† | 56.3 ± 3.1† | 91.4 ± 4.4 |
| AP half-width (ms) | |||
| Slowτ/lowA | 1.33 ± 0.04 | 1.05 ± 0.09 | 0.70 ± 0.06 |
| Slowτ/highA | 1.14 ± 0.02‡ | 1.20 ± 0.12 | 0.67 ± 0.07 |
| Fastτ/lowA | 1.17 ± 0.02† | 1.21 ± 0.12 | 0.64 ± 0.07 |
| Fastτ/highA | 1.16 ± 0.01† | 1.13 ± 0.10 | 0.59 ± 0.04 |
| AP delay (ms) | |||
| Slowτ/lowA | 5.5 ± 0.4 | 3.1 ± 0.1 | 3.1 ± 0.3 |
| Slowτ/highA | 4.6 ± 0.3 | 2.7 ± 0.2† | 3.3 ± 0.5 |
| Fastτ/lowA | 4.6 ± 0.3 | 2.6 ± 0.3† | 3.0 ± 0.1 |
| Fastτ/highA | 4.5 ± 0.3 | 2.5 ± 0.2‡ | 3.4 ± 0.2 |
| Rebound dep (mV) | |||
| Slowτ/lowA | 4.3 ± 0.9 | 3.8 ± 0.5 | 6.9 ± 0.2‡ |
| Slowτ/highA | 5.4 ± 2.2 | 6.3 ± 0.3† | 7.0 ± 0.9 |
| Fastτ/lowA | 5.5 ± 1.3 | 7.7 ± 0.7‡ | 6.7 ± 0.2 |
| Fastτ/highA | 7.0 ± 0.8‡ | NA | 6.2 ± 0.2 |
Presented as mean ± S.E.M. Emboldened numbers represent control conditions. Significant difference from control condition
†
P < 0.05
‡
P < 0.01, Student's paired t test. Rebound dep, rebound depolarisations. NA, not available.