Fig. 5.

Schematic model of the mode of homotypic interaction of Mst1 and heterotypic interaction with RASSF family proteins (See Discussion). (A) The Mst1 kinase domain is linked to the SARAH dimer through a flexible linker, which enables the kinase domain to perform autophosphorylation. (B) The Ras association domain of RASSF family tumor suppressors is linked to their SARAH domain, which mediates heterotypic interaction with Mst kinases. This interaction may induce the colocalization of the RASSF family tumor suppressors with MST kinases in the apoptosis pathway.