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. 2007 May 21;104(22):9254–9259. doi: 10.1073/pnas.0700332104

Fig. 1.

Fig. 1.

Hinge element connecting the FMN subdomain in NOS. (A) The two hinge regions (Oxy-FMN and FMN-FNR) that connect the FMN subdomain in NOS enzymes. (B) Structure and subdomain organization of the nNOS reductase domain. The 25-residue FMN–FNR hinge (purple) links the FMN domain (yellow) to the rest of the reductase domain. Cofactors: orange, FMN; blue, FAD; red, NADP. FNR, ferredoxin NADP-reductase; other abbreviations are as described in the text. (C) Alignment of FMN–FNR hinge region of various NOS enzymes.