Table 1.

Association analysis of LRP6 SNPs in the Multicenter case-control series

Strata	SNP	Sample	MAF Controls	MAF Cases	P	OR (95% CI)
All	14e	Combined	18.7	15.1	0.075	1.30 (0.97:1.71)
		Zurich	22.9	18.5	0.24	1.31 (0.83:2.07)
		U.K.	17.1	14.2	0.43	1.25 (0.71:2.20)
		U.S.	15.1	13.5	0.61	1.14 (0.70:1.86)
	18e	Combined	5.9	8.9	0.037	1.54 (1.03:2.31)
		Zurich	5.8	13.5	0.0048	2.54 (1.30:4.94)
		U.K.	5.5	10.1	0.111	1.93 (0.85:4.41)
		U.S.	6.3	5.4	0.66	1.81 (0.60:2.35)
APOE4-ε4-negative	14e	Combined	18.2	14.8	0.24	1.29 (0.84:1.97)
		Zurich	22.2	21.2	0.87	1.06 (0.53:2.11)
		U.K.	17	13.8	0.54	1.28 (0.58:2.80)
		U.S.	14.7	10.7	0.38	1.44 (0.64:3.23)
	18e	Combined	4.9	10.2	0.0075	2.20 (1.22:3.98)
		Zurich	6.3	15.6	0.025	2.74 (1.11:6.82)
		U.K.	2.8	12.5	0.0083	4.91 (1.36:17.8)
		U.S.	4.7	3.4	0.76	0.72 (0.19:2.76)

Allelic P values. SNP IDs 14e, rs2302685; 18e, rs1012672; MAF, minimal allele frequency; CI, confidence interval; OR, odds ratio.