Table 2.
LRP6 tagging SNPs and haplotype association results in the nonstratified Zurich series
| Stat | SNP ID/haplotype | Allele/frequency | Case, control ratios | χ2 | P |
|---|---|---|---|---|---|
| Single marker | rs7316466 (1) | T, C | 133 : 77, 168 : 120 | 1.27 | 0.26 |
| rs2284396 (2) | T, C | 122 : 90, 157 : 133 | 0.58 | 0.45 | |
| 18e, rs1012672 (3) | C, T | 166 : 26, 243 : 15 | 7.94 | 0.0048 | |
| 14e, rs2302685 (4) | T, C | 163 : 37, 205 : 6 | 1.35 | 0.25 | |
| rs7294695 (5) | C, G | 123 : 89, 159 : 131 | 0.51 | 0.48 | |
| rs2417086 (6) | A, G | 118 : 90, 147 : 137 | 1.19 | 0.28 | |
| rs7308022 (7) | A, G | 192 : 16, 265 : 21 | 0.02 | 0.88 | |
| Haplotype (12345) | TCCTG | 43 | 87.6 : 124.4, 128.3 : 161.7 | 0.44 | 0.51 |
| CTCCC | 20.3 | 39.5 : 172.5, 62.5 : 227.5 | 0.65 | 0.42 | |
| CTCTC | 17.9 | 35.0 : 177.0, 54.7 : 235.3 | 0.47 | 0.5 | |
| TTCTC | 8.6 | 20.4 : 191.6, 22.6 : 267.4 | 0.53 | 0.47 | |
| TTTTC | 8.4 | 26.2 : 185.8, 16.1 : 273.9 | 7.3 | 0.0069 |