Table 3.
Association of LRP6 SNPs 14e and 18e in the NIMH ASP sample
| Stat/strata | Allele | Haplotype | Frequency | Families | Z score | P | p_2side |
|---|---|---|---|---|---|---|---|
| Single marker/all | 14e | C | 20.4 | 80 | — | 0.68 | — |
| 18e | T | 9 | 51 | — | 0.26 | — | |
| APOE-ε4 negative | 14e | C | 21.7 | 14 | — | 0.026 | — |
| 18e | T | 8.5 | 7 | — | 0.049 | — | |
| Haplotype/all | 14e, 18e | TC | 75.4 | 100 | −0.35 | 0.72 | 0.7 |
| CC | 17.9 | 81 | −0.93 | 0.35 | 0.37 | ||
| TT | 6.7 | 53 | 1.64 | 0.1 | 0.078 | ||
| Global | — | — | — | 0.23 | 0.29 | ||
| APOE-ε4 negative | 14e,18e | TC | 73.1 | 17 | −2.96 | 0.003 | 0.0029 |
| CC | 20 | 16 | 1.64 | 0.1 | 0.12 | ||
| TT | 6.9 | 7.7 | 2.19 | 0.029 | 0.031 | ||
| Global | — | — | — | 0.017 | 0.0079 |
Results of FBAT single-locus and HBAT haplotype (univariate) and multihaplotype (global) tests for LRP6 SNPs 14e: rs2302685 and 18e: 1012672. Families, number of informative pedigrees; Z score, FBAT Z statistics. P value, FBAT or HBAT nominal P value. P_2side, Monte Carlo-based two-tailed P value.