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Daclizumab inhibits CD40L expression independently of cell division in memory CD4+ T cells
| CD45RA |
Cell divisions at 48 hrs |
Total | ||
|---|---|---|---|---|
| % Divided | 2 | 1 | 0 | |
| Control | 7 (4) | 54 (4) | 40 (6) | 100% |
| Daclizumab | 0 | 37 (6) | 64 (6) | 100% |
| % CD40L+ | 2 | 1 | 0 | Total |
| Control | 5 (3) | 38 (6) | 20 (2) | 63% |
| Daclizumab | 0 | 13 (5) | 14 (3) | 27% |
Results shown are mean (± SE) of 4 donors.
