Figure 3.

Two examples of squamous lesions signed out as atypical immature metaplasia. A cervical biopsy specimen of a 32-year-old woman (a–c) revealing a flat squamous lesion several cell layers thick with disorderly stratification and nuclear enlargement (a). In step sections, the dysplastic features become more prominent and p16 stains strongly positive (b), while cytokeratin (CK) 17 is largely negative (c). Another cervical biospy of a 40-year-old woman (d–f) shows a squamous lesion involving an endocervical gland. p63 highlights the nuclei of basal and suprabasal cells (d), while p16 (e) shows strong uniform positivity of the entire stratified epithelium and CK17 stains the basal proliferating cells (f).