Table 1.

Summary of immunohistochemical staining profile, atypical immature metaplasia and cervical intraepithelial neoplasia (CIN) III

	p16	CK17	p63
Ectocervix, mature metaplasia	Negative	Negative	Basal cell nuclei
Immature metaplasia	Negative	Positive in all proliferating cells	Basal/suprabasal cell nuclei of proliferating cells
CIN III	Positive in all dysplastic cells	Negative in dysplastic cells	Nuclei of all dysplastic cells
Atypical immature metaplasia (AIM)	10/20 positive*	10/20 negative	Full-thickness positivity
	7/20 negative†	7/20 positive	Basal/suprabasal nuclei
	3/20 positive*	3/20 positive	Basal/suprabasal nuclei to full-thickness positivity

^*Reclassified as CIN III.

^†Reclassified as immature metaplasia.