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Cathepsin D (A) and LAMP-1 (B), detected by immunohistochemistry, are increased in TAB ventricle and in beclin 1 Tg LV, indicative of increased lysosomal activity. Scale bars: 40 μm. (C) Representative immunoblots probed for cathepsin D in ventricular lysates as indicated. *P < 0.05 versus WT sham.
