Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2007 May 30;7:57. doi: 10.1186/1471-213X-7-57

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2007 Li et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

CDK4 inhibitor impairs mGlu-LTD in the hippocampal CA1 region. (A, B) DHPG-induced LTD. Slices were treated with 100 μM DHPG for 5 min (arrow). The effect is prominent in control slices (n = 11 slices), but impaired in CDK4 inhibitor reincubated slices (n = 12 slices) at both P8-15 and P21-35. The effects of the CDK4 inhibitor at slices from adolescent animals were not as robust as slices from neonatal animals on this form of LTD. (C, D) PP-LFS-induced LTD. The protocol consisted in pairs of stimuli with a 50 ms interstimulus interval, delivered at 1Hz for 15 min (1800 pulses total) in the presence of DL-AP-5 (100 μM). CDK4 inhibitor also inhibited this form of LTD. (E, F) Pooled data show that CDK4 was not required for NMDA receptor-dependent LTD induced by LFS (900 pulses at 1 Hz).