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Diagram of tau fragments and cleavage sites. The tau isoform htau40 and positions of FTDP17-mutations ΔK280 and P301L are shown at the top. Then repeat domain K18ΔK280 (M-Q244-E372) and fragments F1, F2, and F3 are shown. Scissors indicate cleavage sites behind K257 (site S1) and near residue 360 (sites S2 and S3). To block the cleavage of K18ΔK280, constructs K18ΔK280/257A or 257R were cloned where K257 was replaced either by A257 or R257.
