Fig. 1.

Structural connectivity and network hubs. (A) Large-scale anatomical connection matrix of macaque neocortex. (B) Ranking of areas for flow/clustering ratio. Flow/clustering ratios for each region are compared with those obtained from 1,000 degree-matched, randomized networks. Regions with significantly increased flow/clustering ratio (P < 0.05, uncorrected) are shown in dark gray. (C) Ranking of areas for betweenness centrality. Regions with significantly increased (P < 0.05) centrality are shown in dark gray. (D) Ranking of areas for motif count of the motif class shown in Inset. Dark gray bars indicate that the area shows increased motif counts (z-score > 2) relative to random and lattice controls.