Fig. 1.

Genome-wide promoter association of NC2α. (a) Structure of the NC2–TBP–TATA complex (31) and of the TFIIB–TBP–TATA complex (38). (b) Charts showing the distribution of enrichment classes of 24,099 human promoters in a NC2α ChIP (Left) and an isotype IgG control ChIP (Right) performed in LCL721 B cells. Five enrichment classes were ranked according to the indicated median fold enrichments on 15 probes per individual promoter. (c) Distribution of the distance between NC2α-bound probes and the closest transcription start site (TSS). The fraction of bound probes that map to 100-bp intervals from the TSS at the indicated cut-offs is shown. The averaged distribution of the nonthresholded NC2α (no cut-off) and control ChIPchip set is also depicted.